Interactions Between Muscle Tissues and Bone Metabolism

@article{Kawao2015InteractionsBM,
  title={Interactions Between Muscle Tissues and Bone Metabolism},
  author={N. Kawao and H. Kaji},
  journal={Journal of Cellular Biochemistry},
  year={2015},
  volume={116}
}
  • N. Kawao, H. Kaji
  • Published 2015
  • Biology, Medicine
  • Journal of Cellular Biochemistry
Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive syndrome and increased number of older people. Sarcopenia is defined by decreased muscle mass and impaired muscle function, which may be associated with frailty. Several clinical data have indicated that increased muscle mass is related to increased bone mass and reduced fracture risk. Genetic, endocrine and mechanical factors as well as inflammatory and nutritional states concurrently affect muscle… Expand
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References

SHOWING 1-10 OF 61 REFERENCES
Interaction between Muscle and Bone
  • H. Kaji
  • Medicine
  • Journal of bone metabolism
  • 2014
TLDR
The findings suggest the presence of interactions between muscle and bone, which might be very important for understanding the physiology and pathophysiology of sarcopenia and osteoporosis. Expand
Linkage between muscle and bone: common catabolic signals resulting in osteoporosis and sarcopenia
  • H. Kaji
  • Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2013
TLDR
A novel local regulator that might induce osteoblast differentiation of myoblasts is found that is crucial for the development of novel drugs for sarcopenia and osteoporosis, as well as for the understanding of the physiological and pathological relationships of muscle and bone. Expand
Genetics of the Musculoskeletal System: A Pleiotropic Approach
  • D. Karasik, D. Kiel
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2008
TLDR
This Perspective will provide the evidence for a shared genetic influence on bone and muscle, seeking to unravel some of the contradictory findings published thus far and provide indications that there are pleiotropic relationships between bone structure/mass and muscle mass/function. Expand
Osteosarcopenic obesity: the role of bone, muscle, and fat on health
TLDR
Interventions that utilize resistance training exercise in conjunction with increased protein intake appear to be promising in their ability to counteract osteosarcopenic obesity. Expand
Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis
TLDR
It is demonstrated that osteoporosis is associated with a preferential type II muscle fiber atrophy, which correlates with bone mineral density and reduced levels of Akt, a major regulator of muscle mass, which is connected to the functional impairment caused by the disease. Expand
Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin‐like growth factor binding protein‐2 levels in adult women and men
TLDR
Association between appendicular skeletal muscle mass (ASM) relative to height squared (relative ASM) and bone parameters at several sites assessed by conventional as well as high‐resolution peripheral QCT in a cohort of 272 women and 317 men are examined to provide new insights into potential biomarkers that reflect the health of the musculoskeletal system. Expand
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study
TLDR
The importance of GLYAT gene in co-regulation of bone phenotypes and body lean mass is suggested, suggesting the gene’s dual role in both bone development and muscle growth. Expand
Role of Osteoglycin in the Linkage between Muscle and Bone*
TLDR
Comp comparative DNA microarray analysis between mouse myoblastic C2C12 cells transfected with either stable empty vector or ALK2, the mutation that constitutively activates the bone morphogenetic protein (BMP) receptor, suggests that OGN may be a crucial humoral bone anabolic factor that is produced by muscle tissues. Expand
Evidence for an Interaction Between Exercise and Nutrition for Improving Bone and Muscle Health
TLDR
There is evidence that combining calcium (or calcium rich dairy foods) or dietary protein with exercise can have a synergetic effect on bone mass and muscle health, respectively, but many questions still remain as to whether there is a threshold level for these nutrients to optimize the exercise-induced gains. Expand
FAM5C is a soluble osteoblast differentiation factor linking muscle to bone.
TLDR
The present study is the first to show that FAM5C enhances osteoblast differentiation in differentiated osteoblasts, and that the effects of the conditioned medium from FAM 5C-modulated myoblastic cells were positively correlated with the effect of FAM5 C on osteobine phenotype in osteoblast. Expand
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