Interactions Between Grapefruit Juice and Cardiovascular Drugs

@article{Bailey2004InteractionsBG,
  title={Interactions Between Grapefruit Juice and Cardiovascular Drugs},
  author={D. Bailey and G. Dresser},
  journal={American Journal of Cardiovascular Drugs},
  year={2004},
  volume={4},
  pages={281-297}
}
Grapefruit juice can alter oral drug pharmacokinetics by different mechanisms. Irreversible inactivation of intestinal cytochrome P450 (CYP) 3A4 is produced by commercial grapefruit juice given as a single normal amount (e. g. 200–300mL) or by whole fresh fruit segments. As a result, presystemic metabolism is reduced and oral drug bioavailability increased. Enhanced oral drug bioavailability can occur 24 hours after juice consumption. Inhibition of P-glycoprotein (P-gp) is a possible mechanism… Expand
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