Interactions Between Grapefruit Juice and Cardiovascular Drugs

@article{Bailey2004InteractionsBG,
  title={Interactions Between Grapefruit Juice and Cardiovascular Drugs},
  author={David G Bailey and George K Dresser},
  journal={American Journal of Cardiovascular Drugs},
  year={2004},
  volume={4},
  pages={281-297}
}
Grapefruit juice can alter oral drug pharmacokinetics by different mechanisms. Irreversible inactivation of intestinal cytochrome P450 (CYP) 3A4 is produced by commercial grapefruit juice given as a single normal amount (e. g. 200–300mL) or by whole fresh fruit segments. As a result, presystemic metabolism is reduced and oral drug bioavailability increased. Enhanced oral drug bioavailability can occur 24 hours after juice consumption. Inhibition of P-glycoprotein (P-gp) is a possible mechanism… 
An overview of interactions between grapefruit juice and drugs
TLDR
The cause of this food-drug interaction is examined, the list of affected medications is discerned and the pharmacist is equipped with this knowledge and their role in counselling patients on options to avoid the possibility of a grapefruit- drug interaction is specified.
Grapefruit-Drug Interactions
TLDR
The aim of this review is to outline the mechanisms of grapefruit-drug interactions and present a comprehensive summary of those agents affected and whether they are likely to be of clinical relevance.
Medicinal importance of grapefruit juice and its interaction with various drugs
TLDR
The phytochemistry of grapefruit Juice, the various drugs involved in the drug – grapefruit juice eraction with their mechanisms of action and the clinical implications of these interactions are discussed.
Interaction Between Grapefruit Juice and Drugs
TLDR
While the research of the possible effects of other not yet identified components of the grapefruit juice is still in progress, FDA has begun to put cautionary statement to many drug prescriptions.
Interactions between grapefruit juice and calcium channel antagonists.
TLDR
The main mechanism for enhanced bioavailability of drugs by grapefruit juice is, presumably, the inhibition of cytochrome P4503A4 in the small intestine and only to a minor extent affected by P-glycoprotein function.
Undesirable Effects of Citrus Juice on the Pharmacokinetics of Drugs
TLDR
It is recommended that patients avoid citrus juice intake while taking medications and that healthcare providers advise against citrus Juice intake in this setting until any interactions with subject drugs can be clarified in clinical studies.
Clinically Significant Grapefruit Juice-Drug Interactions
TLDR
For some drugs such as felodipine and nicardipine, the increased drug concentrations could potentially be associated with an increased frequency of dose-dependent adverse effects, although actual reports of toxicity with drugYgrapefruit juice interactions have been rare.
Grapefruit‐Drug Interactions: Can Interactions With Drugs Be Avoided?
TLDR
A comprehensive summary of underlying mechanisms of interaction and human clinical trials performed in the area of grapefruit drug interactions is provided to point out possible replacements for drugs with a high potential for interactions.
Analysis of Drug Interactions Involving Fruit Beverages and Organic Anion‐Transporting Polypeptides
TLDR
A review of clinical trials indicates that grapefruit juice (GFJ), orange juice (OJ), and apple juice can reduce oral bioavailability of fexofenadine, potentially reducing pharmacodynamic effects ofFexofanadine.
Management of Drug Interactions with Grapefruit
TLDR
Characteristics of oral medications that may interact with grapefruit include extensive metabo- lism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index.
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