• DOI:10.2165/00129784-200404050-00002
Corpus ID: 11525439

Interactions Between Grapefruit Juice and Cardiovascular Drugs

@article{Bailey2004InteractionsBG,
  title={Interactions Between Grapefruit Juice and Cardiovascular Drugs},
  author={D. Bailey and G. Dresser},
  journal={American Journal of Cardiovascular Drugs},
  year={2004},
  volume={4},
  pages={281-297}
}

D. Bailey, G. Dresser

Published 2004

Medicine

American Journal of Cardiovascular Drugs

Grapefruit juice can alter oral drug pharmacokinetics by different mechanisms. Irreversible inactivation of intestinal cytochrome P450 (CYP) 3A4 is produced by commercial grapefruit juice given as a single normal amount (e. g. 200–300mL) or by whole fresh fruit segments. As a result, presystemic metabolism is reduced and oral drug bioavailability increased. Enhanced oral drug bioavailability can occur 24 hours after juice consumption. Inhibition of P-glycoprotein (P-gp) is a possible mechanism… CONTINUE READING

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