Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

@article{Cayrol1998InteractionWC,
  title={Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21},
  author={Corinne Cayrol and Bernard Ducommun},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={2437-2444}
}
The cyclin-dependent kinase (CDK) inhibitor p21Cip1/Waf1 plays an essential role in the control of cell proliferation by modulating the activity of cyclin/CDK complexes in response to various intracellular or extracellular signals. Small variations in p21 expression levels may determine whether it acts as an inhibitor or an assembly factor for cyclin/CDK… CONTINUE READING