Interaction with Vesicle Luminal Protachykinin Regulates Surface Expression of δ-Opioid Receptors and Opioid Analgesia

@article{Guan2005InteractionWV,
  title={Interaction with Vesicle Luminal Protachykinin Regulates Surface Expression of δ-Opioid Receptors and Opioid Analgesia},
  author={Ji-Song Guan and Z Xu and Hua Gao and Shao-Qiu He and Guo-qiang Ma and Tao Sun and Lihua Wang and Zhen-ning Zhang and Isabelle L{\'e}na and I. Kitchen and Robert Elde and Andreas Zimmer and Cheng He and Gang Pei and Lan Bao and Xu Sunny Zhang},
  journal={Cell},
  year={2005},
  volume={122},
  pages={619-631}
}
Opioid and tachykinin systems are involved in modulation of pain transmission in the spinal cord. Regulation of surface opioid receptors on nociceptive afferents is critical for opioid analgesia. Plasma-membrane insertion of delta-opioid receptors (DORs) is induced by stimulus-triggered exocytosis of DOR-containing large dense-core vesicles (LDCVs), but how DORs become sorted into the regulated secretory pathway is unknown. Here we report that direct interaction between protachykinin and DOR is… CONTINUE READING
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A role for heterodimerization of mu and delta opi - te receptors in enhancing morphine analgesia

  • I. omes, A. Gupta, J. Filipovska, H. H. Szeto, J. E. Pintar, L. A. evi
  • Proc . Natl . Acad . ci . USA
  • 2004

A role for heterodimerization of mu and delta opite receptors in enhancing morphine

  • I. omes, A. Gupta, J. Filipovska, H. H. Szeto, J. E. Pintar, L. A. evi
  • analgesia. Proc. Natl. Acad. ci
  • 2004

Activation f delta opioid receptors induces receptor insertion and neuropepide secretion

  • L. ao, S. X. Jin, +8 authors J.S
  • Neuron
  • 2003

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