Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

@article{Wang2003InteractionWT,
  title={Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.},
  author={Huamin Wang and Xiaodong Wang and Yu Jiang},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 11},
  pages={
          4342-51
        }
}
In Saccharomyces cerevisiae, Pph21 and Pph22 are the two catalytic subunits of type 2A phosphatase (PP2Ac), and Sit4 is a major form of 2A-like phosphatase. The function of these phosphatases requires their association with different regulatory subunits. In addition to the conventional regulatory subunits, namely, the A and B subunits for Pph21/22 and the Sap proteins for Sit4, these phosphatases have been found to associate with a protein termed Tap42. In this study, we demonstrated that Sit4… CONTINUE READING

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