Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53.

@article{Zimmermann2000InteractionWC,
  title={Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53.},
  author={H. Zimmermann and C. H. Koh and R. Degenkolbe and M. O'Connor and A. Mueller and G. Steger and J. Chen and Y. Lui and E. Androphy and H. Bernard},
  journal={The Journal of general virology},
  year={2000},
  volume={81 Pt 11},
  pages={
          2617-23
        }
}
  • H. Zimmermann, C. H. Koh, +7 authors H. Bernard
  • Published 2000
  • Biology, Medicine
  • The Journal of general virology
  • The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription… CONTINUE READING
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