Interaction studies with moclobemide

  title={Interaction studies with moclobemide},
  author={Robert H. Zimmer and R. Gieschke and Rolf Fischbach and Silvio Basic},
  journal={Acta Psychiatrica Scandinavica},
Drug interactions with moclobemide given to healthy subjects and depressed patients are reviewed. The drugs investigated for safety were antihypertensives, digoxin, oral contraceptives, anticoagulants and benzodiazepines. Cimetidine was studied for the pharmacokinetic effect, and possible interactions with alcohol (stimulation and/or sedation) were included. Finally, since inhibition of monoamine oxidase (MAO) can increase noradrenergic transmission, possible interaction with neuronal reuptake… Expand
Moclobemide: therapeutic use and clinical studies.
  • U. Bonnet
  • Psychology, Medicine
  • CNS drug reviews
  • 2003
Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) and has been extensively evaluated in the treatment of a wide spectrum of depressive disorders and less extensively studied inExpand
Moclobemide : An Update of its Pharmacological Properties and Therapeutic Use.
Comparative studies have established that moclobemide is better tolerated at therapeutic dosages and has less toxicity in overdose than TCAs and nonselective, irreversible MAO inhibitors, and is also effective in patients with a primary diagnosis of social phobia. Expand
Modification of the cardiovascular effects of ephedrine by the reversible monoamine oxidase A-inhibitor moclobemide.
The combined use of moclobemide and high doses of sympathomimetic drugs should be approached with caution because of the incidence of adverse events elicited by ephedrine, particularly palpitations and headache. Expand
Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study.
VPA does not significantly affect PK or metabolism ofMCB, whereas CBZ time-dependently decreases MCB exposure, probably by inducing metabolism of MCB and its major plasma metabolite. Expand
Clinical Pharmacokinetics of the Monoamine Oxidase-A Inhibitor Moclobemide
Moclobemide is an example of a reversible MAO-A inhibitor which has been extensively studied and whose pharmacokinetic, clinical pharmacological and toxicological profiles have been thoroughly defined, and has an excellent tolerability profile both within the therapeutic dose range and in overdose. Expand
Moclobemide. A review of its pharmacological properties and therapeutic use in depressive illness.
With its efficacy against endogenous and nonendogenous depression, relatively rapid onset of antidepressant activity, and absence of carry-over effects on treatment withdrawal, moclobemide is likely to make an important contribution to the treatment of major depressive illness. Expand
Interactions Between Psychotropics, Anaesthetics and Electroconvulsive Therapy
The anaesthesiologist should remain vigilant at all times, as untoward responses during ECT might occur suddenly due to interactions between psychotropics, anaesthetic agents and/or ECT. Expand
A review of the reversible MAO‐A inhibitor moclobemide in geriatric patients
A comparison of the relevant literature shows that moclobemide has advantages over other, classic, antidepressants because of better tolerability, fewer side effects and interactions, shorter latency of effect, and lower toxicity. Expand
Antidepressant Use in the Elderly
Analysis of data from phase II and III trials showed that venlafaxine was comparably effective in the young and in a subset of over 350 elderly patients, and nefazodone and moclobemide have comparable efficacy in older and younger patients. Expand
Moclobemide and fluvoxamine co‐administration: A prospective study in healty volunteers to investigate the potential development of the ‘serotonin syndrome’
The combined administration of moclobemide, a novel, selective and reversible inhibitor of MAO‐A and fluvoxamine, a selective serotonin re‐uptake inhibitor, was studied in 25 healthy male volunteers. Expand


Review of Cimetidine Drug Interactions
Cimetidine, through its effect on gastric pH, may increase the absorption of acid-labile drugs or may decrease theabsor of drugs, and there have been reports of increased potential for myelosuppression when cimetidine is administered concurrently with drugs capable of causing bone marrow suppression. Expand
Combined Tricyclic—MAOI Therapy for Refractory Depression: A Review, with Guidelines for Appropriate Usage
The issue concerning the intrinsic safety and value of MAOIs is beyond the scope of this paper, but it may be safe to say that its use in combination therapy with TCAs does not outweigh the risks. Expand
Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving
It seems as if doxepin and amitriptyline but not nortriptylines or chlorimipramine, in combination with 0.5 gm/kg of alcohol, may be especially dangerous in driving. Expand
Clinical pharmacology of monoamine oxidase inhibitors.
Monoamine oxidase and disease
  • 1984
Amitriptyl - ine protects patients on MA 01 from tyramine reactions
  • J Clin Psychopharmacol
  • 1982
Amitriptyline protects patients on MAOIs from tyramine reactions.
Combined tricyclic - MA 01 therapy for refractory depression : a review , with guidelines for appropriate use
  • J Clin Pharmacol
  • 1978
Influence of moclobemide ( Ro 11 - 1 163 ) on the peripheral adrenergic system : interaction with tyramine and tricyclic antidepressants