Interaction proteomics: characterization of protein complexes using tandem affinity purification-mass spectrometry.

@article{Vlkel2010InteractionPC,
  title={Interaction proteomics: characterization of protein complexes using tandem affinity purification-mass spectrometry.},
  author={Pamela V{\"o}lkel and Perrine Le Faou and Pierre-Olivier Angrand},
  journal={Biochemical Society transactions},
  year={2010},
  volume={38 4},
  pages={883-7}
}
Most cellular processes are carried out by a multitude of proteins that assemble into multimeric complexes. Thus a precise understanding of the biological pathways that control cellular events relies on the identification and on the biochemical characterization of the proteins involved in such multimeric assemblies. Advances in MS have made possible the identification of multisubunit protein complexes isolated from cell lysates with high sensitivity and accuracy, whereas the TAP (tandem… CONTINUE READING

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