Interaction products of cytotoxic Cu(I) complexes with different solvent mixtures: an electrospray ionization mass spectrometry and density functional theory study.

@article{Tisato2017InteractionPO,
  title={Interaction products of cytotoxic Cu(I) complexes with different solvent mixtures: an electrospray ionization mass spectrometry and density functional theory study.},
  author={Francesco Tisato and Daniel Forrer and Sergio Tamburini and Andrea Vittadini and Pietro Traldi and Marina Porchia},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2017},
  volume={31 2},
  pages={179-192}
}
RATIONALE [Cu(P)4 ][BF4 ]-type complexes (P = tertiary phosphine) have shown significant antitumor activity. This biological property appears to be activated via formation of coordinative unsaturated [Cu(P)n ]+ species (n < 4), that may interact with various molecules starting from the solvent(s) in which they are dissolved. Aim of our study was to investigate the interaction of these species with different solvent mixtures. METHODS The interaction has been investigated by electrospray… CONTINUE READING

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Dimethyl sulfoxide ( DMSO ) and acetonitrile ( MeCN ) strongly affect [ Cu(P)n ] + assemblies producing mixed - ligand [ Cu(P)(DMSO)]+ and [ Cu(P)(MeCN)]+ species .
Dimethyl sulfoxide ( DMSO ) and acetonitrile ( MeCN ) strongly affect [ Cu(P)n ] + assemblies producing mixed - ligand [ Cu(P)(DMSO)]+ and [ Cu(P)(MeCN)]+ species .
Excess of both DMSO and MeCN solvents are able to fully displace coordinated phosphines giving [ Cu(solv)2 ] + -type adducts .
Dimethyl sulfoxide ( DMSO ) and acetonitrile ( MeCN ) strongly affect [ Cu(P)n ] + assemblies producing mixed - ligand [ Cu(P)(DMSO)]+ and [ Cu(P)(MeCN)]+ species .
Dimethyl sulfoxide ( DMSO ) and acetonitrile ( MeCN ) strongly affect [ Cu(P)n ] + assemblies producing mixed - ligand [ Cu(P)(DMSO)]+ and [ Cu(P)(MeCN)]+ species .
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