Interaction paths promote module integration and network-level robustness of spliceosome to cascading effects

@inproceedings{Guimaraes2018InteractionPP,
  title={Interaction paths promote module integration and network-level robustness of spliceosome to cascading effects},
  author={Paulo Roberto Guimaraes and Mathias Mistretta Pires and Maur{\'i}cio Cantor and Patr{\'i}cia P. Coltri},
  booktitle={Scientific Reports},
  year={2018}
}
The functionality of distinct types of protein networks depends on the patterns of protein-protein interactions. A problem to solve is understanding the fragility of protein networks to predict system malfunctioning due to mutations and other errors. Spectral graph theory provides tools to understand the structural and dynamical properties of a system based on the mathematical properties of matrices associated with the networks. We combined two of such tools to explore the fragility to… CONTINUE READING
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