Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?

Abstract

Transcription factor ZNF384/CIZ/NMP4 was first cloned in rat as a p130Cas-binding protein and has a role in bone metabolism and spermatogenesis. It is recurrently involved in translocations in acute lymphoblastic leukemia. Translocations t(12;17) and t(12;22) fuse ZNF384 to RNA-binding proteins TAF15 and EWSR1, while a translocation t(12;19) generates an E2A/ZNF384 fusion. We screened for ZNF384 interacting proteins using yeast two-hybrid technology. In contrast to its rat homolog, human ZNF384 does not interact with p130CAS. Zyxin, PCBP1, and vimentin, however, were identified as ZNF384-binding partners. Given the interaction between human zyxin and p130CAS, these results suggest that zyxin indirectly enables the interaction of ZNF384 with p130CAS which is described in rat.

Cite this paper

@article{Janssen2006InteractionPF, title={Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?}, author={Hilde L K Janssen and Peter Marynen}, journal={Experimental cell research}, year={2006}, volume={312 7}, pages={1194-204} }