Interaction of viable group A streptococci and hydrogen peroxide in killing of vascular endothelial cells.

@article{Ginsburg1993InteractionOV,
  title={Interaction of viable group A streptococci and hydrogen peroxide in killing of vascular endothelial cells.},
  author={Isaac Ginsburg and James Varani},
  journal={Free radical biology & medicine},
  year={1993},
  volume={14 5},
  pages={495-500}
}
Previous studies have shown that the streptococcal hemolysin, streptolysin S, is capable of interacting with hydrogen peroxide (H2O2) to injure vascular endothelial cells (Free Radic. Biol. Med. 7:369-376; 1989). To extend these observations, intact group A streptococci (strain 203S) were examined for ability to injure endothelial cells alone and for ability to injure the same cells in the presence of sublethal concentrations of H2O2 (generated from glucose/glucose oxidase). While neither… CONTINUE READING