Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock*

@article{Russell2009InteractionOV,
  title={Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock*},
  author={James A Russell and Keith R. Walley and Anthony C. Gordon and D. James Cooper and Paul Hebert and Joel Singer and Cheryl Lynn Holmes and Sangeeta Mehta and John T. Granton and Michelle M Storms and Deborah J. Cook and Jeffrey J Presneill},
  journal={Critical Care Medicine},
  year={2009},
  volume={37},
  pages={811-818}
}
Objective:Vasopressin and corticosteroids are often added to support cardiovascular dysfunction in patients who have septic shock that is nonresponsive to fluid resuscitation and norepinephrine infusion. However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment. Design:Post hoc substudy of a multicenter randomized blinded controlled trial of vasopressin vs. norepinephrine in septic shock. Setting:Twenty-seven Intensive Care Units in Canada, Australia, and the… Expand
The Interaction of Vasopressin and Corticosteroids in Septic Shock: A Pilot Randomized Controlled Trial*
TLDR
Hydrocortisone spared vasopressin requirements, reduced duration, and reduced dose, when used together in the treatment of septic shock, but it did not alter plasma vasopressedin levels. Expand
Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.
TLDR
Among adults with septic shock, the early use of vasopressin compared with norepinephrine did not improve the number of kidney failure-free days and the confidence interval included a potential clinically important benefit for vasoppressin. Expand
Arginine Vasopressin for the Treatment of Septic Shock in Adults
TLDR
Results of the a priori and post hoc analyses of this trial suggest that patients may benefit if arginine vasopressin is used in patients with less severe shock, defined as those receiving a relatively low norepinephrine‐equivalent dose, or in those at risk for renal failure. Expand
Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients: The VANCS II Randomized Clinical Trial.
TLDR
In cancer patients with septic shock, vasopressin as first-line vasopressor therapy was not superior to norepinephrine in reducing 28-day mortality rate. Expand
Predictors of response to fixed-dose vasopressin in adult patients with septic shock
TLDR
45% responded to the addition of vasopressin with improved outcomes compared to non-responders, and factors not associated with response included APACHE III score, SOFA score, corticosteroid use, and catecholamine dose. Expand
Does body weight impact the efficacy of vasopressin therapy in the management of septic shock?
TLDR
Effectes of vasopressin on catecholamine dosing requirements in the setting of septic shock may be influenced by body weight. Expand
Vasopressin for Septic Shock in a Medical-Surgical Intensive Care Unit.
TLDR
Vasopressin dosing was comparable to that reported elsewhere; however, discontinuation practices were inconsistent and correlation with improvement in clinical outcomes, such as mortality or ICU length of stay, is unclear, and further research is required to determine the ideal approach to vasopressingin use. Expand
Concomitant vasopressin and hydrocortisone therapy on short‐term hemodynamic effects and vasopressor requirements in refractory septic shock
TLDR
Concomitant AVP and HCT may have an immediate, additive effect as a catecholamine‐sparing agent in septic shock patientsNorepinephrine dose reductions by ≥50% were more common with combination therapy and sustained up to 24 hours. Expand
therapy in Septic sHock ( VANISH ) VAsopressin versus Noradrenaline as Initial Protocol for a randomised controlled trial of and
Correspondence to Dr Anthony C Gordon; anthony.gordon@imperial.ac. uk ABSTRACT Introduction: Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine useExpand
Discontinuation of vasopressin before norepinephrine increases the incidence of hypotension in patients recovering from septic shock: a retrospective cohort study.
TLDR
Discontinuation of AVP before NE may lead to a higher incidence of hypotension in patients recovering from septic shock receiving concomitant AVP and NE. Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Vasopressin versus norepinephrine infusion in patients with septic shock.
TLDR
Low-dose vasopressin did not reduce mortality rates as compared with norepinephrine among patients with septic shock who were being treated with conventional (catecholamine) vasopressesors, and a test for heterogeneity between these two study strata was not significant. Expand
Beneficial Effects of Short-term Vasopressin Infusion during Severe Septic Shock
TLDR
It is concluded that short-term vasopressin infusion spared conventional vasopressor use and improved some measures of renal function in patients with severe septic shock. Expand
The effects of vasopressin on hemodynamics and renal function in severe septic shock: a case series
TLDR
In this group of patients with severe septic shock, vasopressin infusion increased MAP and urine output and decreased catecholamine requirements and may have been associated with higher adverse effects. Expand
Hydrocortisone therapy for patients with septic shock.
TLDR
Hydrocortisone did not improve survival or reversal of shock in patients with septic shock, either overall or in patients who did not have a response to corticotropin, although hydroc Cortisone hastened reversal ofshock in patients in whom shock was reversed. Expand
Endocrinologic response to vasopressin infusion in advanced vasodilatory shock*
TLDR
The preliminary results of this study indicate that a combined AVP and NE infusion increases prolactin plasma concentrations in advanced vasodilatory shock and Hemodynamic effects of AVP infusion are independent of baseline plasma AVP concentrations. Expand
Comparison of two dose regimens of arginine vasopressin in advanced vasodilatory shock
TLDR
AVP dosages of 0.067IU/min seem to be more effective to reverse cardiovascular failure in vasodilatory shock requiring high norepinephrine dosages than 0.033 IU/min. Expand
METHYLPREDNISOLONE REVERSES VASOPRESSIN HYPORESPONSIVENESS IN OVINE ENDOTOXEMIA
TLDR
The present study demonstrates that in endotoxemia, the vasopressor effect of AVP infusion may be reduced, corticosteroids may potentially be useful to increase the efficacy of A VP infusion, and even moderate AVP doses may potentially impair myocardial and hepatic function. Expand
Sepsis in European intensive care units: Results of the SOAP study*
TLDR
This large pan-European study documents the high frequency of sepsis in critically ill patients and shows a close relationship between the proportion of patients with sepsi and the intensive care unit mortality in the various countries. Expand
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.
TLDR
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality. Expand
Has the mortality of septic shock changed with time.
TLDR
There was an increasing prevalence of Gram-positive causative organisms, and a change of the predominant origin of sepsis from the abdomen to the chest, in patients with bacteremia as an entry criterion. Expand
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