Interaction of vasoactive intestinal peptide with human blood mononuclear cells.

@article{Guerrero1981InteractionOV,
  title={Interaction of vasoactive intestinal peptide with human blood mononuclear cells.},
  author={Juan M. Guerrero and Juan C. Prieto and F L Elorza and Ray Ramirez and Raimundo Goberna},
  journal={Molecular and cellular endocrinology},
  year={1981},
  volume={21 2},
  pages={151-60}
}
The binding of vasoactive intestinal peptide (VIP) and the stimulation of adenylate cyclase were studied in mononuclear cells from human peripheral blood. The binding depended on time, temperature and pH, and was reversible, saturable and specific. Binding studies suggested the presence of 2 classes of binding site: a class with high affinity (Kd = 2.4 X 10(-10)M) and low capacity (8 fmoles/10(6) cells), and a class with low affinity (Kd = 8.0 X 10(-8)M) and high capacity (800 fmoles/10(6… CONTINUE READING

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