Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.

@article{Wu2000InteractionOT,
  title={Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.},
  author={Yan Wu and Donald Dowbenko and Susan Spencer and Righetti Laura and Jae-young Lee and Qihai Gu and Laurence A. Lasky},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 28},
  pages={21477-85}
}
PTEN/MMAC is a phosphatase that is mutated in multiple human tumors. PTEN/MMAC dephosphorylates 3-phosphorylated phosphatidylinositol phosphates that activate AKT/protein kinase B (PKB) kinase activity. AKT/PKB is implicated in the inhibition of apoptosis, and cell lines and tumors with mutated PTEN/MMAC show increased AKT/PKB kinase activity and resistance to apoptosis. PTEN/MMAC contains a PDZ domain-binding site, and we show here that the phosphatase binds to a PDZ domain of membrane… CONTINUE READING

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