Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity.

@article{Alexander2012InteractionOT,
  title={Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity.},
  author={Nina C. Alexander and Tim Klucken and Georgia Koppe and Roman Osinsky and Bertram Walter and Dieter Vaitl and Gebhard Sammer and Rudolf Stark and J{\"u}rgen Hennig},
  journal={Biological psychiatry},
  year={2012},
  volume={72 1},
  pages={49-56}
}
BACKGROUND Gene by environment (G×E) interaction between genetic variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) and stressful life events (SLEs) has been extensively studied in the context of depression. Recent findings suggest increased neural and endocrine stress sensitivity as a possible mechanism conveying elevated vulnerability to psychopathology. Furthermore, these G×E mediated alterations very likely reflect… CONTINUE READING
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