Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).

@article{Yang2010InteractionOT,
  title={Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).},
  author={Weng-Lang Yang and Roald Ravatn and Kazuya Kudoh and Leah Alabanza and Khew-Voon Chin},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={391 3},
  pages={1318-23}
}
The effects of cAMP in cell are predominantly mediated by the cAMP-dependent protein kinase (PKA), which is composed of two genetically distinct subunits, catalytic (C) and regulatory (R), forming a tetrameric holoenzyme R(2)C(2). The only known function for the R subunit is that of inhibiting the activity of the C subunit kinase. It has been shown that overexpression of RIalpha, but not the C subunit kinase, is associated with neoplastic transformation. In addition, it has also been… CONTINUE READING