Interaction of the receptor tyrosine kinase p145c‐kit with the p210bcr/abl kinase in myeloid cells

@article{Hallek1996InteractionOT,
  title={Interaction of the receptor tyrosine kinase p145c‐kit with the p210bcr/abl kinase in myeloid cells},
  author={M. Hallek and S. Danhauser-Riedl and Ronald Herbst and M. Warmuth and A. Winkler and H. Kolb and B. Druker and J. Griffin and B. Emmerich and A. Ullrich},
  journal={British Journal of Haematology},
  year={1996},
  volume={94}
}
  • M. Hallek, S. Danhauser-Riedl, +7 authors A. Ullrich
  • Published 1996
  • Biology, Medicine
  • British Journal of Haematology
  • The chimaeric bcr/abl oncogene is detected in virtually all cases of chronic myelogenous leukaemia (CML). It encodes a constitutively active tyrosine kinase of 210kDalton, p210bcr/abl, which stimulates a variety of cytosolic signalling intermediates. The effects of bcr/abl on the activity of growth factor receptors are less well known. In order to investigate interaction of p210bcr/abl with the receptor tyrosine kinase p145c‐kit, we used two myeloid, factor‐dependent cell lines, MO7 and 32D, to… CONTINUE READING
    52 Citations
    The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X.
    • C. Oetzel, T. Jonuleit, +5 authors W. Aulitzky
    • Biology, Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2000
    • 82
    Activation of Src Kinases p 53 / 56 @ and p 59 hck by @ in Myeloid Cells '
    • Susanne, Danhauser-Riedi, +7 authors HaIlek
    • 2006
    • 4
    • PDF
    Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells
    • 114
    • PDF
    Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
    • 71
    • PDF

    References

    SHOWING 1-10 OF 60 REFERENCES
    BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
    • 657
    • Highly Influential
    Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia.
    • 197
    • PDF
    Modulation of p145c-kit function in cells of patients with acute myeloblastic leukemia.
    • 17
    • Highly Influential