Interaction of the receptor tyrosine kinase p145c‐kit with the p210bcr/abl kinase in myeloid cells

  title={Interaction of the receptor tyrosine kinase p145c‐kit with the p210bcr/abl kinase in myeloid cells},
  author={M. Hallek and S. Danhauser-Riedl and Ronald Herbst and M. Warmuth and A. Winkler and H. Kolb and B. Druker and J. Griffin and B. Emmerich and A. Ullrich},
  journal={British Journal of Haematology},
  • M. Hallek, S. Danhauser-Riedl, +7 authors A. Ullrich
  • Published 1996
  • Biology, Medicine
  • British Journal of Haematology
  • The chimaeric bcr/abl oncogene is detected in virtually all cases of chronic myelogenous leukaemia (CML). It encodes a constitutively active tyrosine kinase of 210kDalton, p210bcr/abl, which stimulates a variety of cytosolic signalling intermediates. The effects of bcr/abl on the activity of growth factor receptors are less well known. In order to investigate interaction of p210bcr/abl with the receptor tyrosine kinase p145c‐kit, we used two myeloid, factor‐dependent cell lines, MO7 and 32D, to… CONTINUE READING
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