Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells.

@article{Hallek1996InteractionOT,
  title={Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells.},
  author={Michael J. Hallek and Susanne Danhauser-Riedl and Ronald Herbst and Markus Warmuth and Anja Winkler and Hans Jochem Kolb and Brian Druker and James D Griffin and Bertold Emmerich and Axel Prof Dr Ullrich},
  journal={British journal of haematology},
  year={1996},
  volume={94 1},
  pages={
          5-16
        }
}
The chimaeric bcr/abl oncogene is detected in virtually all cases of chronic myelogenous leukaemia (CML). It encodes a constitutively active tyrosine kinase of 210 kDalton, p210bcr/abl, which stimulates a variety of cytosolic signalling intermediates. The effects of bcr/abl on the activity of growth factor receptors are less well known. In order to investigate interaction of p210bcr/abl with the receptor tyrosine kinase p145c-kit, we used two myeloid, factor-dependent cell lines, MO7 and 32D… CONTINUE READING
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