Interaction of the pneumococcal amidase with lipoteichoic acid and choline.

  title={Interaction of the pneumococcal amidase with lipoteichoic acid and choline.},
  author={Thomas Briese and Regine Hakenbeck},
  journal={European journal of biochemistry},
  volume={146 2},
The choline-containing lipoteichoic acid (LTA, Forssman Antigen) of Streptococcus pneumoniae suppresses the activity of the pneumococcal autolysin, an N-acetyl-muramoyl-L-alanine-amidase (amidase) in aqueous solution [Höltje and Tomasz (1975) Proc. Natl Acad. Sci. USA 72, 1690-1694]. The interaction between LTA and enzyme was used to establish a purification by affinity chromatography on LTA-Sepharose. The amidase could be eluted from the column with choline only. This implies that binding of… CONTINUE READING


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