Interaction of the novel agent amphethinile with tubulin.

  title={Interaction of the novel agent amphethinile with tubulin.},
  author={A. McGown and B. Fox},
  journal={British Journal of Cancer},
  pages={865 - 868}
The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule. 

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