Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases.

@article{James2007InteractionOT,
  title={Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases.},
  author={Andrew M. James and Mark S. Sharpley and A B Manas and Frank E. Frerman and Judy Hirst and Robin A. J. Smith and Michael P Murphy},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 20},
  pages={14708-18}
}
MitoQ(10) is a ubiquinone that accumulates within mitochondria driven by a conjugated lipophilic triphenylphosphonium cation (TPP(+)). Once there, MitoQ(10) is reduced to its active ubiquinol form, which has been used to prevent mitochondrial oxidative damage and to infer the involvement of reactive oxygen species in signaling pathways. Here we show MitoQ(10) is effectively reduced by complex II, but is a poor substrate for complex I, complex III, and electron-transferring flavoprotein (ETF… CONTINUE READING