Interaction of the mediator head module with RNA polymerase II.

@article{Cai2012InteractionOT,
  title={Interaction of the mediator head module with RNA polymerase II.},
  author={Gang Cai and Yuriy L. Chaban and Tsuyoshi Imasaki and Julio A. Kovacs and Guillermo Calero and Pawel A. Penczek and Yuichiro Takagi and Francisco J. Asturias},
  journal={Structure},
  year={2012},
  volume={20 5},
  pages={899-910}
}
Mediator, a large (21 polypeptides, MW ∼1 MDa) complex conserved throughout eukaryotes, plays an essential role in control of gene expression by conveying regulatory signals that influence the activity of the preinitiation complex. However, the precise mode of interaction between Mediator and RNA polymerase II (RNAPII), and the mechanism of regulation by Mediator remain elusive. We used cryo-electron microscopy and reconstituted in vitro transcription assays to characterize a transcriptionally… CONTINUE READING
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