Interaction of the human autoantigen p150 with splicing snRNPs.

@article{Blencowe1993InteractionOT,
  title={Interaction of the human autoantigen p150 with splicing snRNPs.},
  author={Benjamin J. Blencowe and Maria Carmo-Fonseca and Sven Erik Behrens and Reinhard L{\"u}hrmann and Angus I. Lamond},
  journal={Journal of cell science},
  year={1993},
  volume={105 ( Pt 3)},
  pages={685-97}
}
An important goal of studies on pre-mRNA splicing is to identify factors that mediate the snRNP-snRNP and snRNP-pre-mRNA interactions that take place in the spliceosome. The U4/U6 snRNP is one of the four snRNPs that are subunits of spliceosomes. A rare patient autoimmune serum (MaS serum) has recently been identified that specifically immunoprecipitates U4/U6 snRNP from HeLa cell extracts through recognition of a 150 kDa autoantigen (p150) (Okano and Medsger, Journal of Immunology, 146, 535… CONTINUE READING

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