Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.

@article{Dou2008InteractionOT,
  title={Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.},
  author={Hong Dou and Corey A. Theriot and Aditi Das and Muralidhar L Hegde and Yoshihiro Matsumoto and Istvan Boldogh and Tapas K Hazra and Kishor K. Bhakat and Sankar Mitra},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 6},
  pages={3130-40}
}
NEIL1 and NEIL2 compose a family of DNA glycosylases that is distinct from that of the other two DNA glycosylases, OGG1 and NTH1, all of which are involved in repair of oxidized bases in mammalian genomes. That the NEIL proteins, unlike OGG1 and NTH1, are able to excise base lesions from single-stranded DNA regions suggests their preferential involvement in repair during replication and/or transcription. Previous studies showing S phase-specific activation of NEIL1, but not NEIL2, suggested… CONTINUE READING

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