Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.

@article{Ng2002InteractionOT,
  title={Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.},
  author={Enders Kai On Ng and Kwok Keung Chan and Chi Hang Wong and Stephen Kwok-Wing Tsui and Sai Ming Ngai and Simon Ming-yuen Lee and Masayo Kotaka and Cheuk Yu Lee and Mary Miu Yee Waye and K. P. Fung},
  journal={Journal of cellular biochemistry},
  year={2002},
  volume={84 3},
  pages={556-66}
}
Using a yeast two-hybrid library screen, we have identified that the heart specific FHL2 protein, four-and-a-half LIM protein 2, interacted with human DNA-binding nuclear protein, hNP220. Domain studies by the yeast two-hybrid interaction assay revealed that the second LIM domain together with the third and the fourth LIM domains of FHL2 were responsible to the binding with hNP220. Using green fluorescent protein (GFP)-FHL2 and blue fluorescent protein (BFP)-hNP220 fusion proteins co-expressed… CONTINUE READING
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