Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.

@article{Frank1994InteractionOT,
  title={Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.},
  author={Stuart J. Frank and Gary Gilliland and Andrew S. Kraft and C. S. Arnold},
  journal={Endocrinology},
  year={1994},
  volume={135 5},
  pages={2228-39}
}
An early step in GH action involves tyrosine phosphorylation of various cellular proteins. Recently, it has been shown in murine preadipocytes that GH promotes the association of its receptor (the GHR) with and the activation of the JAK2 tyrosine kinase. In this study, we confirmed the human (h) GH-induced association of JAK2 with hGHR in IM-9 cells by coimmunoprecipitation experiments using anti-hGHR serum. We further examined the interaction of JAK2 with the GHR cytoplasmic domain by two… CONTINUE READING

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