Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.

@article{Lukhele2013InteractionOT,
  title={Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.},
  author={Sabelo Lukhele and Alaji Bah and Hong Li Lin and Nahum Sonenberg and Julie Deborah Forman-Kay},
  journal={Structure},
  year={2013},
  volume={21 12},
  pages={
          2186-96
        }
}
Cap-dependent translation initiation is regulated by the interaction of eukaryotic initiation factor 4E (eIF4E) with eIF4E binding proteins (4E-BPs). Whereas the binding of 4E-BP peptides containing the eIF4E-binding ⁵⁴YXXXXLΦ⁶⁰ motif has been studied, atomic-level characterization of the interaction of eIF4E with full-length 4E-BPs has been lacking. Here, we use isothermal titration calorimetry and nuclear magnetic resonance spectroscopy to characterize the dynamic, structural and binding… CONTINUE READING
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