Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor.

@article{Algaier2008InteractionOT,
  title={Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor.},
  author={Irina Algaier and Joseph A. Jakubowski and Fumitoshi Asai and Ivar von K{\"u}gelgen},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 11},
  pages={1908-14}
}
BACKGROUND The P2Y(12) receptor plays a crucial role in platelet aggregation and is the target of platelet aggregation inhibitors, including the thienopyridine compound prasugrel. OBJECTIVE The present study analyzed the effects of R-138727 (2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic acid), the active metabolite of prasugrel, on recombinant wild-type and mutant human P2Y(12) receptors in order to identify the molecular site of action of R-138727… CONTINUE READING