Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.

  title={Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.},
  author={Yingqing Sun and Xuan Liu and Elinor Ng. Eaton and William S. Lane and Harvey F. Lodish and Robert A Weinberg},
  journal={Molecular cell},
  volume={4 4},
TGF-beta treatment of cells induces a variety of physiologic responses, including growth inhibition, differentiation, and induction of apoptosis. TGF-beta induces phosphorylation and nuclear translocation of Smad3. We describe here the association of Smad3 with the nuclear protooncogene protein Ski in response to the activation of TGF-beta signaling. Association with Ski represses transcriptional activation by Smad3, and overexpression of Ski renders cells resistant to the growth-inhibitory… CONTINUE READING