Interaction of the Salmonella typhimurium transcription and virulence factor SlyA with target DNA and identification of members of the SlyA regulon.

@article{Stapleton2002InteractionOT,
  title={Interaction of the Salmonella typhimurium transcription and virulence factor SlyA with target DNA and identification of members of the SlyA regulon.},
  author={Melanie R. Stapleton and Valia A Norte and Robert C Read and Jeffrey Green},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={17630-7}
}
The SlyA protein from Salmonella typhimurium is a transcription factor that contributes to virulence. It is shown that a slyA mutant is attenuated in the presence of murine macrophages compared with the parent strain. Moreover, after growth in minimal medium, survival of the slyA mutant was reduced. Altered levels of flagellin (fliC), PagC, IroN, and outer membrane proteins suggest that the slyA mutation affects the surface properties of Salmonella. The isolated SlyA protein is a cofactor-free… CONTINUE READING