Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis.

@article{Ramesh2008InteractionOT,
  title={Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis.},
  author={Geeta Ramesh and Juan Toribio Borda and Jason Dufour and Deepak Kaushal and Ramesh Ramamoorthy and Andrew A Lackner and Mario T. Philipp},
  journal={The American journal of pathology},
  year={2008},
  volume={173 5},
  pages={
          1415-27
        }
}
Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi, often manifests by causing neurocognitive deficits. As a possible mechanism for Lyme neuroborreliosis, we hypothesized that B. burgdorferi induces the production of inflammatory mediators in the central nervous system with concomitant neuronal and/or glial apoptosis. To test our hypothesis, we constructed an ex vivo model that consisted of freshly collected slices from brain cortex of a rhesus macaque and allowed live B… CONTINUE READING

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Microglia in Infectious Diseases of the Central Nervous System

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