Interaction of the Effects of Alcohol Drinking and Polymorphisms in Alcohol-Metabolizing Enzymes on the Risk of Female Breast Cancer in Japan

@inproceedings{Kawase2009InteractionOT,
  title={Interaction of the Effects of Alcohol Drinking and Polymorphisms in Alcohol-Metabolizing Enzymes on the Risk of Female Breast Cancer in Japan},
  author={Takakazu Kawase and Keitaro Matsuo and Akio Hiraki and Takeshi Suzuki and Miki Watanabe and Hiroji Iwata and Hideo Tanaka and Kazuo Tajima},
  booktitle={Journal of epidemiology},
  year={2009}
}
BACKGROUND Epidemiological studies consistently indicate that alcoholic beverages are an independent risk factor for female breast cancer. Although the mechanism underlying this effect remains unknown, the predominant hypothesis implicates mutagenesis via the ethanol metabolite acetaldehyde, whose impact on the carcinogenesis of several types of cancer has been shown in both experimental models and molecular epidemiological studies. Many of the epidemiological studies have investigated genetic… CONTINUE READING

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