Interaction of the σ2 Receptor Ligand PB28 with the Human Nucleosome: Computational and Experimental Probes of Interaction with the H2A/H2B Dimer

@article{Abate2010InteractionOT,
  title={Interaction of the $\sigma$2 Receptor Ligand PB28 with the Human Nucleosome: Computational and Experimental Probes of Interaction with the H2A/H2B Dimer},
  author={Carmen Abate and Justin E. Elenewski and Mauro Niso and Francesco Berardi and Nicola Antonio Colabufo and Amalia Azzariti and Roberto Perrone and Richard A Glennon},
  journal={ChemMedChem},
  year={2010},
  volume={5}
}
Sigma‐2 (σ2) binding sites are an emerging target for anti‐neoplastic agents due to the strong apoptotic effect exhibited by σ2 agonists in vitro and the overexpression of these sites in tumor cells. Nonetheless, no σ2 receptor protein has been identified. Affinity chromatography using the high‐affinity σ2 ligand PB28 and human SK‐N‐SH neuroblastoma cells was previously utilized to identify σ2 ligand binding proteins, specifically histones H1, H2A, H2B, and H3.3a. To rationalize this finding… 
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