Interaction of talin with actin: sensitive modulation of filament crosslinking activity.

@article{Schmidt1999InteractionOT,
  title={Interaction of talin with actin: sensitive modulation of filament crosslinking activity.},
  author={Jonathan M. Schmidt and Jie Zhang and H S Lee and Marvin H. Stromer and Richard M. Robson},
  journal={Archives of biochemistry and biophysics},
  year={1999},
  volume={366 1},
  pages={139-50}
}
Talin is an adhesion plaque protein believed important in linking actin filaments to the plasma membrane. The nature of a direct talin-actin interaction, however, is complex and has remained unclear. We have systematically characterized the effects of pH, ionic strength, temperature, and protein molar ratio on the interaction between highly purified talin and actin. The ability of talin to increase viscosity of F-actin at 25 degrees C and low ionic strength increased with decreasing pH from 7.3… CONTINUE READING