Interaction of synthetic peptide octarphin with rat myocardium membranes

@article{Nekrasova2011InteractionOS,
  title={Interaction of synthetic peptide octarphin with rat myocardium membranes},
  author={Yu. N. Nekrasova and Yu. A. Zolotarev and Elena V. Navolotskaya},
  journal={Biochemistry (Moscow)},
  year={2011},
  volume={76},
  pages={1337-1341}
}
A selective agonist of non-opioid β-endorphin receptor synthetic peptide octarphin (TPLVTLFK, specific activity 28 Ci/mmol) was prepared. The [3H]octarphin binding to rat myocardium membranes before and after experimental myocardial infarction (EMI) was studied. It was found that [3H]octarphin with high affinity and specificity binds to non-opioid β-endorphin receptor of rat myocardium membranes before EMI: Kd1 value of the [3H]octarphin specific binding to membranes was 1.8 ± 0.2 nM. In 3 h… 
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