Interaction of synthetic peptide octarphin with human blood lymphocytes

@article{Nekrasova2013InteractionOS,
  title={Interaction of synthetic peptide octarphin with human blood lymphocytes},
  author={Y. N. Nekrasova and Y. Zolotarev and E. V. Navolotskaya},
  journal={Biochemistry (Moscow)},
  year={2013},
  volume={78},
  pages={309-313}
}
The synthetic peptide octarphin (TPLVTLFK, fragment 12–19 of β-endorphin), a selective agonist of nonopioid β-endorphin receptor, was prepared with specific activity 28 Ci/mmol. The binding of [3H]octarphin to T and B lymphocytes isolated from the blood of donors was studied. It was found that [3H]octarphin binds both to T and B cells with high affinity: Kd = 3.0 ± 0.2 and 3.2 ± 0.3 nM, respectively. The specific binding of [3H]octarphin to T and B lymphocytes was competitively inhibited by… Expand
3 Citations

Figures, Tables, and Topics from this paper

The second life of antibodies
Endogenous opiates and behavior: 2013

References

SHOWING 1-10 OF 40 REFERENCES
The synthetic peptide octraphin TPLVTLFK is a selective agonist of nonopioid β-endorphin receptor
Binding of synthetic peptide TPLVTLFK to nonopioid beta‐endorphin receptor on rat brain membranes
Binding of synthetic fragments of β‐endorphin to nonopioid β‐endorphin receptor
Detection of nonopioid β‐endorphin receptor in the rat myocardium
Synthetic peptide TPLVTLFK (octarphin) reduces the corticosterone production by rat adrenal cortex through nonopioid β‐endorphin receptor
Characteristics of Non-opioid β-Endorphin Receptor
beta-Endorphin enhances lymphocyte proliferative responses.
...
1
2
3
4
...