Interaction of synthetic peptide octarphin (TPLVTLFK) with human blood lymphocytes

@article{Nekrasova2013InteractionOS,
  title={Interaction of synthetic peptide octarphin (TPLVTLFK) with human blood lymphocytes},
  author={Y. N. Nekrasova and E. V. Navolotskaya},
  journal={Journal of Peptide Science},
  year={2013},
  volume={19}
}
The synthetic peptide octarphin (TPLVTLFK) corresponding to the sequence 12–19 of β‐endorphin, a selective agonist of non‐opioid β‐endorphin receptor, was labeled with tritium to specific activity of 29 Ci/mmol. The analysis of [3H]octarphin binding to human T and B lymphocytes separated from normal human blood revealed the existence of one type of high‐affinity binding sites (receptors): Kd 3.0 and 3.2 nM, respectively. Besides unlabeled octarphin, unlabeled β‐endorphin possessed the ability… Expand
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