Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins.

@article{Volosin2006InteractionOS,
  title={Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins.},
  author={Marta Volosin and Wenyu Song and Ramiro D. Almeida and David R Kaplan and Barbara L. Hempstead and Wilma J Friedman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 29},
  pages={7756-66}
}
Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via p75NTR even in cells expressing survival-promoting Trk receptors. In the CNS, basal forebrain (BF) neurons are particularly vulnerable to degeneration in Alzheimer's disease, and are among the few populations of brain neurons that express p75NTR throughout life. These neurons also express Trk receptors and may be… CONTINUE READING
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Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor are distinguished during morphogenesis of transgenic animals

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