Interaction of stereoisomers of barbiturates with [3H]alpha-dihydropicrotoxinin binding sites.


Racemic depressant barbiturates inhibit the binding of gamma-aminobutyric acid antagonist [3H]alpha-dihydropicrotoxinin (DHP) to rat brain membranes with IC50 values ranging from 5 to 50 microM. The (-) isomers of pentobarbital and secobarbital were three to four-fold more potent that their (+) isomers in inhibiting [3H]DHP binding. In contrast, the… (More)


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