Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.

@article{Barnathan1990InteractionOS,
  title={Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.},
  author={Elliot S. Barnathan and Alice Kuo and Louis Rosenfeld and Katalin Karik{\'o} and Michel Leski and Federico Robbiati and M. Luisa Nolli and Jack Henkin and Douglas B Cines},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 5},
  pages={2865-72}
}
The interaction of urokinase-type plasminogen activators with receptors on the surface of endothelial cells may play an important role in the regulation of fibrinolysis and cell migration. Therefore, we investigated whether human umbilical vein endothelial cells (HUVEC) express receptors for single-chain urokinase (scu-PA) on the cell surface and examined the effect of such binding on plasminogen activator activity. Binding of 125I-labeled scu-PA to HUVEC, performed at 4 degrees C, was… CONTINUE READING