Interaction of sildenafil and indinavir when co-administered to HIV-positive patients.

@article{Merry1999InteractionOS,
  title={Interaction of sildenafil and indinavir when co-administered to HIV-positive patients.},
  author={Concepta Merry and Michael G. Barry and M{\'a}ir{\'i}n Ryan and John F Tjia and Martina Hennessy and V A Eagling and Fiona M Mulcahy and David J. Back},
  journal={AIDS},
  year={1999},
  volume={13 15},
  pages={F101-7}
}
OBJECTIVES The prevalence of erectile dysfunction in HIV-infected men is estimated to be 33%. Sildenafil citrate (Viagra; Pfizer Ltd, Sandwich, Kent, UK) is the first oral drug for this condition. Since sildenafil and the protease inhibitors are both metabolized by, and act as inhibitors of cytochrome P450 3A4, we evaluated the pharmacokinetics of the combination sildenafil plus indinavir in HIV-infected patients. DESIGN AND METHODS Six patients at steady state in treatment with indinavir… CONTINUE READING
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