Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma

@article{Xie2013InteractionOS,
  title={Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma},
  author={Jia-xin Xie and Yu-wei Zhang and Q. Zhang and Yifang Han and Jianhua Yin and R. Pu and Qiuxia Shen and W. Lu and Yan Du and J. Zhao and Xue Han and Hongwei Zhang and G. Cao},
  journal={Hepatology},
  year={2013},
  volume={57}
}
Hepatitis B virus (HBV) mutations and signal transducer and activator of transcription 3 (STAT3) activation are closely associated with hepatocellular carcinoma (HCC). However, single nucleotide polymorphisms (SNPs) of STAT3 have not been implicated in HCC susceptibility. This study was designed to evaluate the effect of STAT3 SNPs and their interactions with HBV mutations on HCC risk. A total of 2,011 HBV‐infected subjects (including 1,021 HCC patients) and 1,012 healthy controls were involved… Expand
Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.
TLDR
Positive association of SNP rs7574865 in STAT4 with HCC risk when compared to healthy controls under an additive model and no significant association between rs2293152 and HCC development was observed are suggested. Expand
Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma.
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TLDR
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The rs4938723 variant genotypes in dominant model significantly increased HCC risk in women, compared to female healthy controls and its effect on HCC is significantly affected by the HBV mutations. Expand
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