Interaction of sigma and PCP-like drugs on operant behaviors in the rat

@article{Hudzik1992InteractionOS,
  title={Interaction of sigma and PCP-like drugs on operant behaviors in the rat},
  author={Thomas J. Hudzik and Barbara L. Slifer},
  journal={Psychopharmacology},
  year={1992},
  volume={108},
  pages={115-122}
}
Many PCP-like drugs interact with at least two types of binding sites in the CNS, one of which is linked to excitatory amino acid transmission and the other with an unknown function. The present experiments were designed to further clarify the mechanism of action of drugs in this class. Assessment was made of the effects of PCP, MK-801, (+)-pentazocine, (+)- and (−)-N-allylnormetazocine (NANM), (+)-amphetamine and BMY-14802 in rats responding under a multiple timeout 600 s (TO), differential… CONTINUE READING

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