Interaction of rotavirus polymerase VP1 with nonstructural protein NSP5 is stronger than that with NSP2.

@article{Arnoldi2007InteractionOR,
  title={Interaction of rotavirus polymerase VP1 with nonstructural protein NSP5 is stronger than that with NSP2.},
  author={Francesca Arnoldi and Michela Campagna and Catherine Eichwald and Ulrich Desselberger and Oscar R Burrone},
  journal={Journal of virology},
  year={2007},
  volume={81 5},
  pages={2128-37}
}
Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms. RNA replication and packaging are mediated by several viral proteins, of which VP1, the RNA-dependent RNA polymerase, and VP2, the core scaffolding protein, were shown to be sufficient to provide replicase activity in vitro. In vivo, however, viral replication complexes also contain the nonstructural proteins NSP2 and NSP5, which were shown to be essential for replication, to interact with each other, and to… CONTINUE READING
25 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…