Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor.

@article{Mitton2003InteractionOR,
  title={Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor.},
  author={Kenneth P. Mitton and Prabodh K. Swain and Hemant Khanna and Mary Dowd and Ingrid J. Apel and Anand Swaroop},
  journal={Human molecular genetics},
  year={2003},
  volume={12 4},
  pages={365-73}
}
NRL (neural retina leucine zipper) is a basic motif leucine zipper transcription factor of the Maf-subfamily. Multiple phosphorylated isoforms of NRL are detected specifically in rod photoreceptors. NRL regulates the expression of several rod-specific genes, including rhodopsin and cGMP phosphodiesterase beta-subunit, in synergy with other transcription factors (e.g. the homeodomain protein CRX). Missense mutations in the human NRL gene are associated with autosomal dominant retinitis… CONTINUE READING

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