Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.

@article{Zdzalik2010InteractionOR,
  title={Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.},
  author={Michal Zdzalik and Katarzyna Pustelny and Sylwia Kędracka-Krok and Krzysztof Huben and Aleksandra Pęcak and Benedykt Wladyka and Stefan Jankowski and Adam Dubin and Jan Potempa and Grzegorz Dubin},
  journal={Cell cycle},
  year={2010},
  volume={9 22},
  pages={4584-91}
}
The negative regulation of p53, a major human tumor suppressor, by Mdm2 and Mdmx is crucial for the survival of a cell, whereas its aberrant function is a common feature of cancer.  Both Mdm proteins act through the spatial occlusion of the p53 transactivation (TA) domain and by the ubiquitination of p53, resulting in its degradation.  Two p53 homologues, p63 and p73, have been described in humans.  Unlike p53, these proteins regulate developmental processes rather than genome stability.  Both… CONTINUE READING

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