Interaction of radiosensitizers and WR-2721. I. Modification of skin radioprotection.

@article{Rojas1982InteractionOR,
  title={Interaction of radiosensitizers and WR-2721. I. Modification of skin radioprotection.},
  author={A. R. Vasquez Rojas and Fiona A Stewart and Juliana Denekamp},
  journal={British Journal of Cancer},
  year={1982},
  volume={45},
  pages={684 - 693}
}
We have studied the radiomodifying action in mouse skin of WR-2721 and misonidazole (MISO) when used alone or in combination. The radioprotection with WR-2721 was drug-dose dependent and highly influenced by the O2 concentration at the time of irradiation. Significant sensitizaton was observed with MISO, especially in air-breathing mice. The combination of WR-2721 and MISO produced a radiation response intermediate between the resistant and sensitive responses to either drug alone. The precise… CONTINUE READING
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