Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs.

@article{Ichikawa2000InteractionOP,
  title={Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs.},
  author={J. Ichikawa and A. Norris and M. Bangera and G. Geiss and A. B. van 't Wout and Roger E Bumgarner and S. Lory},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 17},
  pages={
          9659-64
        }
}
  • J. Ichikawa, A. Norris, +4 authors S. Lory
  • Published 2000
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Pseudomonas aeruginosa is an opportunistic pathogen that plays a major role in lung function deterioration in cystic fibrosis patients. To identify critical host responses during infection, we have used high-density DNA microarrays, consisting of 1,506 human cDNA clones, to monitor gene expression in the A549 lung pneumocyte cell line during exposure to P. aeruginosa. We have identified host genes that are differentially expressed upon infection, several of which require interaction with P… Expand
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