Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions.

@article{Meyer1996InteractionOP,
  title={Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions.},
  author={Urs A. Meyer},
  journal={The Yale Journal of Biology and Medicine},
  year={1996},
  volume={69},
  pages={203 - 209}
}
  • Urs A. Meyer
  • Published 1996 in The Yale journal of biology and medicine
Omeprazole, lansoprazole and pantoprazole are metabolized by several human cytochromes P450, most prominently by CYP2C19 and CYP3A4. Only pantoprazole is also metabolized by a sulfotransferase. Differences in the quantitative contribution of these enzymes and in the relative affinities of the substrates explain some of the observed interactions with carbamazepin, diazepam, phenytoin and theophylline and of the impact of the CYP2C19 (mephenytoin) genetic polymorphism. Of these drugs… CONTINUE READING
24 Extracted Citations
36 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 36 references

Pantoprazole does not influence CYP 1 A 2 activity in man

  • M. Hartmann, H. Bliesath, +4 authors H. Mascher
  • Gastroenterol .
  • 1995

Similar Papers

Loading similar papers…